You can use that phrase in so many ways:
“I now realize that there’s no such thing as joking around when it comes to <insert taboo here>.”
My picks for much hilarity:
Feeding kittens to my pet python
Telling people they’re going to hell
Bombing an aeroplane
Telling people that they’re going to hell for bombing an aeroplane (or for feeding kittens to the snake) is okay though.
Feeding kittens to a snake on a plane is moving into Samuel L. Jackson territory and that’s absolutely fair game.
What, dear reader, are your sacrosanct topics of discourse?